Phase I Detoxification (Commentary for polymorphisms may not appear in this section unless the polymorphism has been indicated to have impaired activity.)

Note: In the following charts, substrtates, inhibitors, and inducers are listed for each cytochrome P450 enzyme (Phase I) included in the DetoxiGenomic Profile.

Substrates are compounds that are metabolized by that enzyme. The metabolism of some of these compounds is shared by other P450 enzymes (refer to chart).

Inhibitors may or may not be substrates of that enzyme, but will reliably reduce that enzyme's activity if present.

Inducers also may or may not be substrates, but will tend to increase the enzyme's activity.

Drug Interaction Resources

http://medicine.iupui.edu/flockhart/table.htm